ESPE Yearbook of Paediatric Endocrinology

Brief summary: The objective of this study was to examine whether IGF-I and IGF-binding protein-3 (IGFBP-3) levels track through childhood into adulthood and to estimate the cumulative lifetime exposure to IGF-I in healthy individuals and in individuals with a defined period of increased IGF-I levels because of GH therapy.Measurement of serum IGF-I is a cornerstone in rhGH treatment monitoring. Keeping serum IGF-I concentrations within the normal referen...